Semaglutide
A GLP-1 peptide used for appetite and weight goals.
Available options
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What is it?
Semaglutide is a GLP-1 peptide that works with a natural gut hormone involved in appetite and blood sugar. It is the best known peptide in this category.
Why people choose it
- Works through the GLP-1 pathway
- Used for appetite and weight goals
- Dosed once a week
- The most documented option in this category
What is it used for?
- Appetite and weight goals
- Blood sugar support
- Metabolic health
How it works
Semaglutide mimics GLP-1, a natural gut hormone that helps signal fullness and steady blood sugar.
Good to know
- Same family as Tirzepatide and Retatrutide.
- Dosed once a week.
- Dose is stepped up gradually so your body adjusts comfortably.
Dose calculator
Enter a few details to see an illustrative protocol for this peptide.
Vials/pens to cover the full cycle at this dose.
How a typical cycle is structured over time (for reference).
Start low and step the dose up every few weeks so your body adjusts comfortably. Reconstitute once, then draw more units as you climb.
Each pack includes one peptide vial + a 3 ml bacteriostatic water vial. Add the amount of water shown down the vial wall, then set your U-100 insulin syringe to this mark for each dose.
Dosage protocol
Mixing amounts, dose steps and syringe draw volumes for this peptide.
Mixing (reconstitution)
| Vial | Add BAC water | Concentration | 1 unit (0.01 ml) |
|---|---|---|---|
| 5 mg | 2.0 ml | 2.5 mg/mL | 25 mcg |
Dosing schedule
| Phase | Dose | Units | Volume |
|---|---|---|---|
| Weeks 1–4 | 0.25 mg | 10 units | 0.10 ml |
| Weeks 5–8 | 0.5 mg | 20 units | 0.20 ml |
| Weeks 9–12 | 1.0 mg | 40 units | 0.40 ml |
| Weeks 13–16 | 1.7 mg | 68 units | 0.68 ml |
| Weeks 17+ | 2.4 mg | 96 units | 0.96 ml |
Storage
- Avoid freeze-thaw cycles
Technique
- Clean the vial stopper and the skin with an alcohol swab and let both air-dry.
- Pinch a skinfold and insert the needle at 45–90° into the subcutaneous tissue.
- Do not aspirate for subcutaneous injections. Inject slowly and steadily.
- Wait 5–10 seconds before withdrawing, then apply gentle pressure. Do not rub the site.
- Rotate sites between the abdomen (at least 5 cm from the navel), thighs and upper arms to avoid lipohypertrophy.
- Use a new sterile 28–31 G insulin syringe every time and dispose of it in a sharps container.
Related peptides
Tirzepatide
A dual-action metabolic peptide for appetite and weight.
Retatrutide
A multi-receptor metabolic peptide for appetite and weight.
NAD+
A cellular-energy molecule used for vitality and clarity.